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Drug Incompatibility

Definition
Incompatibility is an undesirable reaction that occurs between the drug and the solution, container or another drug. The two types of incompatibilities associated with intravenous administration are physical and chemical incompatibility1. A drug interaction describes the alteration of a drug effect due to the influence of another substance (i.e. drug, chemical substance, nutrition) resulting in a solution that is no longer optimal for the patient after the substances are mixed2.

Causes
Incompatibilities of drugs can occur between

  • Drugs and inappropriate IV solutions as diluent
  • Two drugs when they are mixed together within the same infusion line and/or IV container
  • Drugs and adjuvants (preservative, buffer, stabilizer, solvent)
  • Drugs and materials of IV containers (e.g. PVC) or medical devices, which can concern the nature of the material used and/or reactions at the inner surface (e.g. adsorption)

ProSet Solutions:

IV-ProSet components

Intrapur® and Sterifix® filters:

CVC-ProSet  components

Certofix® Multilumen Catheters

References:
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1 Josephson 2006, RCN 2005, Douglas et al. 2001
2 Craven et al. 2007a, Josephson 2006, Douglas et al. 2001, Nemec et al. 2008