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Particulate Contamination

Definition
“Particulate contamination” describes the unintended presence of extraneous, mobile and undissolved particles in a parenteral solution. These particles can be of various size, defining them as detectable by visual inspection (in general ≥ 50 µm) sub-visible inspection with a range of 2-50 µm in size in general.

Causes
Several causes of particulate contaminations of IV fluids are known. This is because drugs are available in various containers (for example vials, ampoules, pre-filled containers and premixed solutions) and their usage and manipulations are highly diversified. Consequently, many types of particulate contamination can occur:

  • Glass
  • Plastic
  • Rubber
  • Undissolved particles/drugs

Glass ampoules especially pose a high risk of particulate contamination as glass fragments may enter the ampoule when it is opened1.

ProSet Solutions:
Choose out of the following B. Braun components to create customized kits, which reduce particulate contamination.

IV-ProSet components

Intrapur® and Sterifix® filters:

RA- & CVC-ProSet  components

Sterifix® Filter straw & Sterifx® Filter needle

References:
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1 Douglas et al. 2001